Frühjahrstagung 2022 des AK FTI. Neue Ansprüche an das Monitoring von FTI-Programmen

Assessing Environmental Impacts of the Fti

The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.

Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI) that inhibits the post-translational lipid modification of H-Ras and other farnesylated proteins. K- and N-Ras are also substrates of farnesyl transferase; however, upon treatment with FTIs, they are alternatively prenylated by geranylgeranyl transferase-1. Despite the failure to abrogate prenylation of K- and N-Ras, growth of many...

Das neue TPI - erste Erfahrungen

TPI ist eine weltweit anerkannte Methode zur Testprozessverbesserung. Ein internationales Autorenteam der Firma Sogeti hat zum 17. November 2009 eine neue, völlig überarbeitete Version der Methode angekündigt. Als eine Qualitätssicherungsmaßnahme wurden im August mehrere Feldtests bei Testorganisationen durchgeführt, unter anderem drei in Deutschland. Der Beitrag erläutert die ersten Erfahrunge...

Automatisierte Zeitreihenanalyse von Fernerkundungsdaten für das Monitoring von Oberflächengewässern

Since 2012, the state of California faces an extreme drought, which impacts water supply in many ways. Advanced remote sensing is an important technology to better assess water resources, monitor drought conditions and water supplies, plan for drought response and mitigation, and measure drought impacts. In the present case study latest time series analysis capabilities are used to examine surf...

Characterization of an automated radioimmunoassay for T4, T3, T3 U, and FTI.

The performance characteristics of assays is reported for thyroxine (T4), triiodothyronine (T3), and T3-uptake (T3U) using the GAMMAFLOTM Automated Assay System. A comparison of calculated free thyroxine index (FTI) values is also presented. This automated radioimmunoassay (RIA) system utilizes a combination of continuous-flow methodology and chromatographic separation techniques. The T4 assay ...